Article
Interaction of IFNλR1 with TRAF6 regulates NF-κB activation and IFNλR1 stability.
Journal of cellular biochemistry - 1 Nov 2012
Xie Yun-Fei, Cui Ying-Bin, Hui Xi-Wu, Wang Lan, Ma Xiao-Li, Chen Hong, Wang Xin, Huang Bing-Ren
Abstract excerpt
IFNλR1 is a member of the class II cytokine receptor family, and it associates with IL-10R2 to form a functional receptor complex, IFNλR. This receptor complex transduces signals from IFNλs (IFNλ1, IFNλ2, and IFNλ3), promoting antiviral and antiproliferative activities similar to those of type I IFNs. In an effort to further understand signal transduction through IFNλR1, we used bioinformatics analysis and...
Topics
- Amino Acid Motifs
- Binding Sites
- Computational Biology
- Gene Expression Regulation
- HEK293 Cells
- Humans
- Mutation
- NF-kappa B
- Plasmids
- Protein Binding
- Receptors, Interferon
- Signal Transduction
- TNF Receptor-Associated Factor 6
- Transfection
- Ubiquitination
- Interferon gamma Receptor