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Article

Disorders caused by genetic defects associated with GH-dependent genes: PAPPA2 defects.

Molecular and cellular endocrinology - 1 Dec 2020

Fujimoto Masanobu, Andrew Melissa, Dauber Andrew

Abstract excerpt

Growth hormone (GH) and its mediator, insulin-like growth factor-1 (IGF-1), have long been recognized as central to human growth physiology. IGF-1 is known to complex with IGF binding proteins as well as with the acid labile subunit (ALS) in order to prolong its half-life in circulation. Factors regulating the bioavailability of IGF-1 (i.e. the balance between free and bound IGF-1) were less well understood....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 32739295
DOI: 10.1016/j.mce.2020.110967
PMCID: PMC7609568

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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