Article

Sex-based differences in IGF1 signaling pathways in response to PAPP-A2 deficiency

2023-01-30

Abstract excerpt

<title>Abstract</title> <p>Background. Patients with pregnancy-associated plasma protein-A2 (<italic>PAPP-A2</italic>) mutations have progressive postnatal growth retardation and high circulating levels of IGF1 bound in ternary complexes. The present study aims to assess whether <italic>Pappa2</italic> deficiency is associated with sex-specific differences in the main components of IGF1 ternary complexes and IGF...

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Literature Corpus work: 2ef16901-68d4-57c3-a5b9-fc40d7f72a3e
DOI: 10.21203/rs.3.rs-2489074/v1

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