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Article

PAPP-A2 deficiency does not exacerbate the phenotype of a mouse model of intrauterine growth restriction.

Reproductive biology and endocrinology : RB&E - 12 Jun 2018

Christians Julian K, Lennie Kendra I, Huicochea Munoz Maria F, Binning Nimrat

Abstract excerpt

BACKGROUND: Pregnancy-associated plasma protein-A2 (PAPP-A2) is consistently upregulated in the placentae of pregnancies complicated by preeclampsia and fetal growth restriction. The causes and significance of this upregulation remain unknown, but it has been hypothesized that it is a compensatory response to improve placental growth and development. We predicted that, if the upregulation of PAPP-A2 in pregnancy...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29895300
DOI: 10.1186/s12958-018-0376-4
PMCID: PMC5996520

Genes

MMP9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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