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Article

Further validation to support clinical translation of [18F]FTC-146 for imaging sigma-1 receptors

17 Sept 2015

Abstract excerpt

BACKGROUND: This study aims to further evaluate the specificity and selectivity of [(18)F]FTC-146 and obtain additional data to support its clinical translation. METHODS: The binding of [(19)F]FTC-146 to vesicular acetylcholine transporter (VAChT) was evaluated using [(3)H]vesamicol and PC12(A123.7) cells in an in vitro binding assay. The uptake and kinetics of [(18)F]FTC-146 in S1R-knockout mice (S1R-KO)...

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PMID: 26384292
DOI: 10.1186/s13550-015-0122-2

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