Article
High occupancy of sigma-1 receptors in the human brain after single oral administration of fluvoxamine: a positron emission tomography study using [11C]SA4503.
Biological psychiatry - 15 Oct 2007
Ishikawa Masatomo, Ishiwata Kiichi, Ishii Kenji, Kimura Yuichi, Sakata Muneyuki, Naganawa Mika, Oda Keiichi, Miyatake Ryousuke, Fujisaki Mihisa, Shimizu Eiji, Shirayama Yukihiko, Iyo Masaomi, Hashimoto Kenji
Abstract excerpt
BACKGROUND: Sigma-1 receptors might be implicated in the pathophysiology of psychiatric diseases, as well as in the mechanisms of action of some selective serotonin reuptake inhibitors (SSRIs). Among the several SSRIs, fluvoxamine has the highest affinity for sigma-1 receptors (Ki = 36 nM), whereas paroxetine shows low affinity (Ki = 1893 nM). The present study was undertaken to examine whether fluvoxamine binds...
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