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Article

Mechanism of entecavir resistance of hepatitis B virus with viral breakthrough as determined by long-term clinical assessment and molecular docking simulation.

Antimicrobial agents and chemotherapy - 1 Feb 2010

Mukaide Motokazu, Tanaka Yasuhito, Shin-I Tadasu, Yuen Man-Fung, Kurbanov Fuat, Yokosuka Osamu, Sata Michio, Karino Yoshiyasu, Yamada Gotaro, Sakaguchi Kohsaku, Orito Etsuro, Inoue Manami, Baqai Sumbella, Lai Ching-Lung, Mizokami Masashi

Abstract excerpt

The mechanism by which entecavir resistance (ETVr) substitutions of hepatitis B virus (HBV) can induce breakthrough (BT) during ETV therapy is largely unknown. We conducted a cross-sectional study of 49 lamivudine (LVD)-refractory patients and 59 naïve patients with chronic hepatitis B. BT was ob...

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Identifiers

PMID: 19933798
DOI: 10.1128/AAC.01061-09
PMCID: PMC2812155

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19933798-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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