Article
Analysis of potential antiviral resistance mutation profiles within the HBV reverse transcriptase in untreated chronic hepatitis B patients using an ultra-deep pyrosequencing method.
Diagnostic microbiology and infectious disease - 1 May 2014
Ciftci Sevgi, Keskin Fahriye, Cakiris Aris, Akyuz Filiz, Pinarbasi Binnur, Abaci Neslihan, Dincer Erdinc, Badur Selim, Kaymakoglu Sabahattin, Ustek Duran
Abstract excerpt
The potential antiviral resistance mutations within hepatitis B virus (HBV) reverse transcriptase (RT) region for nucleos(t)ide analogues (NA) are not well known. Especially, the effect of pre-existing antiviral drug resistance mutations in untreated patients in comparison to the resistance developed after treatment is not still clear. Sixteen naive chronic hepatitis B patients were studied. None of the patients...
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