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Article

HCV NS3 quasispecies in liver and plasma and dynamics of telaprevir-resistant variants in breakthrough patients assessed by UDPS: A case study.

Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology - 1 Nov 2015

Bartolini Barbara, Selleri Marina, Garbuglia Anna Rosa, Giombini Emanuela, Taibi Chiara, Lionetti Raffaella, D'Offizi Gianpiero, Capobianchi Maria R

Abstract excerpt

BACKGROUND: The impact of pre-existing variants in hepatitis C virus (HCV) quasispecies, carrying resistance-associated mutations (RAMs), on the outcome of treatment with direct acting antiviral agents (DAA) is debated and it is complicated by the lack of knowledge of quasispecies distribution between the viral reservoir (liver) and the circulating compartment. OBJECTIVE: To evaluate NS3 protease heterogeneity...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 26418073
DOI: 10.1016/j.jcv.2015.07.310

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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