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Article

Effect of common polymorphisms of the farnesoid X receptor and bile acid transporters on the pharmacokinetics of ursodeoxycholic acid.

Clinical and experimental pharmacology & physiology - 1 Jan 2016

Hu Miao, Fok Benny S P, Wo Siu-Kwan, Lee Vincent H L, Zuo Zhong, Tomlinson Brian

Abstract excerpt

Ursodeoxycholic acid (UDCA), a natural, dihydroxy bile acid, promotes gallstone dissolution and has been attributed with several other beneficial effects. The farnesoid X receptor (FXR) may influence the pharmacokinetics of UDCA by modulating the expression of bile acid transporters. This exploratory study examined whether common functional polymorphisms in FXR and in bile acid transporter genes affect the...

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Identifiers

PMID: 26382575
DOI: 10.1111/1440-1681.12490

Genes

ABCB11

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Effect of common polymorphisms of the farnesoid X receptor and bile acid transporters on the pharmacokinetics of ursodeoxycholic acid.PMID 26382575Read ↗

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