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Article

Effects of Polymorphisms in NR1H4, NR1I2, SLCO1B1, and ABCG2 on the Pharmacokinetics of Rosuvastatin in Healthy Chinese Volunteers.

Journal of cardiovascular pharmacology - 1 Nov 2016

Liu Mei, Wu Xiu-Jun, Zhao Gui-Lian, Zhang Ti, Xu Shan-Sen, Sun Ya-Xin, Qiu Feng, Zhao Li-Mei

Abstract excerpt

The nuclear receptors (NR)-farnesoid X receptor (FXR, NR1H4) and pregnane X receptor (PXR, NR1I2)-have important effects on the expression of genes related to the pharmacokinetics (PKs) of rosuvastatin. This study was designed to investigate whether the genetic variants in drug disposition genes (SLCO1B1 and ABCG2) combined with their upstream regulators (NR1H4 and NR1I2) would affect the PKs of rosuvastatin in a...

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Share to ATP Binding Cassette Transporter, Subfamily G, Member 2
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 27557342
DOI: 10.1097/FJC.0000000000000426

Genes

ABCG2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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