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Article

Risk modification of colorectal adenoma by CYP7A1 polymorphisms and the role of bile acid metabolism in carcinogenesis.

Cancer prevention research (Philadelphia, Pa.) - 1 Feb 2012

Wertheim Betsy C, Smith Jeffrey W, Fang Changming, Alberts David S, Lance Peter, Thompson Patricia A

Abstract excerpt

Cholesterol 7α-hydroxylase (CYP7A1), the rate-limiting enzyme in the conversion of cholesterol to bile acids, is a postulated gene modifier of colorectal cancer risk and target for the therapeutic bile acid, ursodeoxycholic acid (UDCA). We investigated associations between CYP7A1 polymorphisms and fecal bile acids, colorectal adenoma (CRA), and UDCA efficacy for CRA prevention. Seven tagging, single-nucleotide...

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Identifiers

PMID: 22058145
DOI: 10.1158/1940-6207.CAPR-11-0320
PMCID: PMC3400261

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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