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Article

The farnesoid X receptor -1G>T polymorphism influences the lipid response to rosuvastatin.

Journal of lipid research - 1 Jul 2012

Hu Miao, Lui Sandra S H, Tam Lai-Shan, Li Edmund K, Tomlinson Brian

Abstract excerpt

The bile acid-activated nuclear receptor farnesoid X receptor (FXR) plays an important role in lipid and glucose metabolism, and in addition, it regulates multiple drug transporters involved in statin disposition. We examined whether a functional single nucleotide polymorphism (SNP) in FXR (-1G>T) influenced the lipid-lowering effect of rosuvastatin. In 385 Chinese patients with hyperlipidemia who had been...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22534644
DOI: 10.1194/jlr.M026054
PMCID: PMC3371250

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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