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Article

Impact of ursodeoxycholic acid on a CCK1R cholesterol-binding site may contribute to its positive effects in digestive function.

American journal of physiology. Gastrointestinal and liver physiology - 1 Sept 2015

Desai Aditya J, Dong Maoqing, Harikumar Kaleeckal G, Miller Laurence J

Abstract excerpt

Dysfunction of the type 1 cholecystokinin (CCK) receptor (CCK1R) as a result of increased gallbladder muscularis membrane cholesterol has been implicated in the pathogenesis of cholesterol gallstones. Administration of ursodeoxycholic acid, which is structurally related to cholesterol, has been shown to have beneficial effects on gallstone formation. Our aims were to explore the possible direct effects and...

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Identifiers

PMID: 26138469
DOI: 10.1152/ajpgi.00173.2015
PMCID: PMC4556949

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CCK

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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