Article
Role of ABCG8 D19H (rs11887534) variant in gallstone susceptibility in northern India.
Journal of gastroenterology and hepatology - 1 Nov 2010
Srivastava Anshika, Srivastava Anvesha, Srivastava Kshitij, Choudhuri Gourdas, Mittal Balraj
Abstract excerpt
BACKGROUND AND AIM: The excretion of cholesterol from the liver is regulated by the ATP-binding cassette transporter ABCG8. A common genetic polymorphism D19H of ABCG8 might be related to the genetic predisposition of gallstone disease, which is causatively related to supersaturation of cholesterol in bile. We aimed to examine the role of the ABCG8 D19H (rs11887534) polymorphism in susceptibility to gallstone...
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