Article
Resistance to protease inhibitors.
Journal of HIV therapy - 1 Nov 2002
Kuritzkes Daniel R
Abstract excerpt
Resistance to HIV-1 protease inhibitors (PIs) limits the benefits of highly active antiretroviral therapy (HAART) and complicates the selection of appropriate salvage therapy for a growing number of patients. Initial patterns of drug resistance depend on the PI used in treatment, viral subtype and level of drug exposure. Impaired replication capacity of PI-resistant viruses contributes to the maintenance of...
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