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Article

Phenotypic characterization of virological failure following lopinavir/ritonavir monotherapy using full-length Gag-protease genes.

The Journal of antimicrobial chemotherapy - 1 Dec 2014

Sutherland Katherine A, Mbisa Jean L, Ghosn Jade, Chaix Marie-Laure, Cohen-Codar Isabelle, Hue Stephane, Delfraissy Jean-Francois, Delaugerre Constance, Gupta Ravindra K

Abstract excerpt

OBJECTIVES: Major protease mutations are rarely observed following first-line failure with PIs and interpretation of genotyping results in this context may be difficult. We performed extensive phenotyping of viruses from five patients failing lopinavir/ritonavir monotherapy in the MONARK study without major PI mutations by standard genotyping. METHODS: Phenotypic susceptibility testing and viral infectivity...

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Share to Anti-HIV Agents
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to gag Gene Products, Human Immunodeficiency Virus

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Source

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Identifiers

PMID: 25096075
DOI: 10.1093/jac/dku296
PMCID: PMC4228778

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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