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Article

Accumulation of HIV-1 drug resistance after continued virological failure on first-line ART in adults and children in sub-Saharan Africa.

The Journal of antimicrobial chemotherapy - 1 Oct 2016

Boender T Sonia, Kityo Cissy M, Boerma Ragna S, Hamers Raph L, Ondoa Pascale, Wellington Maureen, Siwale Margaret, Nankya Immaculate, Kaudha Elizabeth, Akanmu Alani Sulaimon, Botes Mariette E, Steegen Kim, Calis Job C J, Rinke de Wit Tobias F, Sigaloff Kim C E

Abstract excerpt

OBJECTIVES: Limited availability of viral load (VL) monitoring in HIV treatment programmes in sub-Saharan Africa can delay switching to second-line ART, leading to the accumulation of drug resistance mutations (DRMs). The objective of this study was to evaluate the accumulation of resistance to reverse transcriptase inhibitors after continued virological failure on first-line ART, among adults and children in...

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Share to Anti-HIV Agents
Share to Africa South of the Sahara

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Antiretroviral Therapy, Highly Active

Share to Drug Resistance, Viral

Share to HIV Infections

Share to Reverse Transcriptase Inhibitors

Share to Treatment Failure

Share to Viral Load

Source

Identifiers

PMID: 27342546
DOI: 10.1093/jac/dkw218

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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