Article
The MELAS mutation m.3243A>G promotes reactivation of fetal cardiac genes and an epithelial-mesenchymal transition-like program via dysregulation of miRNAs.
Biochimica et biophysica acta. Molecular basis of disease - 1 Sept 2018
Meseguer Salvador, Panadero Joaquin, Navarro-González Carmen, Villarroya Magda, Boutoual Rachid, Comi Giacomo Pietro, Armengod M-Eugenia
Abstract excerpt
The pathomechanisms underlying oxidative phosphorylation (OXPHOS) diseases are not well-understood, but they involve maladaptive changes in mitochondria-nucleus communication. Many studies on the mitochondria-nucleus cross-talk triggered by mitochondrial dysfunction have focused on the role played by regulatory proteins, while the participation of miRNAs remains poorly explored. MELAS (mitochondrial...
Topics
Join the communities discussing this publication.