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Alternative splicing of auxiliary β2-subunits stabilizes Cav2.3 Ca <sup>2+</sup> channel activity in continuously active midbrain dopamine neurons

2021-02-10

Abstract excerpt

In dopaminergic (DA) substantia nigra (SN) neurons Cav2.3 R-type Ca 2+ -currents contribute to somatodendritic Ca 2+ -oscillations. These may contribute to the selective degeneration of these neurons in Parkinson’s disease (PD) since Cav2.3-knockout is neuroprotective in a PD mouse model. However, the typical Cav2.3 gating would predict complete channel inactivation during SN DA neuronal firing. Here we show tha...

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Literature Corpus work
03cd049c-7acb-5bf1-9519-ac3165bd4deb
DOI
10.1101/2021.02.10.430224
Open publication

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Alternative splicing of auxiliary β2-subunits stabilizes Cav2.3 Ca <sup>2+</sup> channel activity in continuously active midbrain dopamine neuronsDOI 10.1101/2021.02.10.430224
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