Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

β2-subunit alternative splicing stabilizes Cav2.3 Ca2+ channel activity during continuous midbrain dopamine neuron-like activity

6 Jul 2022

Abstract excerpt

In dopaminergic (DA) Substantia nigra (SN) neurons Cav2.3 R-type Ca 2+ -currents contribute to somatodendritic Ca 2+ -oscillations. This activity may contribute to the selective degeneration of these neurons in Parkinson’s disease (PD) since Cav2.3-knockout is neuroprotective in a PD mouse model. Here, we show that in tsA-201-cells the membrane-anchored β2-splice variants β2a and β2e are required to stabilize...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cardiac electrophysiology and arrhythmias
Share to Ion channel regulation and function
Share to RNA Research and Splicing

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 35792082
DOI: 10.7554/elife.67464

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 10 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

β2-subunit alternative splicing stabilizes Cav2.3 Ca2+ channel activity during continuous midbrain dopamine neuron-like activityPMID 35792082Read ↗

Alternative splicing of auxiliary β2-subunits stabilizes Cav2.3 Ca <sup>2+</sup> channel activity in continuously active midbrain dopamine neuronsSemantic proximity Read ↗

Compensatory T-type Ca2+ channel activity alters D2-autoreceptor responses of Substantia nigra dopamine neurons from Cav1.3 L-type Ca2+ channel KO mice.Semantic proximity Read ↗

Distribution of Na/K-ATPase alpha 3 isoform, a sodium-potassium P-type pump associated with rapid-onset of dystonia parkinsonism (RDP) in the adult mouse brain.Semantic proximity Read ↗

Functional Impact of Alternative Splicing of Human T-Type Ca<sub>v</sub>3.3 Calcium ChannelsSemantic proximity Read ↗

Amyloid β oligomers enhance presynaptic exocytosis via CaV2.1 to drive disease progression in Alzheimer’s modelsSemantic proximity Read ↗

Identification of functionally distinct isoforms of the N-type Ca2+ channel in rat sympathetic ganglia and brain.Semantic proximity Read ↗

The weaver mouse gain-of-function phenotype of dopaminergic midbrain neurons is determined by coactivation of wvGirk2 and K-ATP channels.Semantic proximity Read ↗

Limiting RyR2 Open Time Prevents Alzheimer's Disease-Related Neuronal Hyperactivity and Memory Loss but Not β-Amyloid Accumulation.Semantic proximity Read ↗

Expression and Pharmacology of Endogenous Cav Channels in SH-SY5Y Human Neuroblastoma CellsSemantic proximity Read ↗

Alternative splicing in the cytoplasmic II-III loop of the N-type Ca channel alpha 1B subunit: functional differences are beta subunit-specific.Semantic proximity Read ↗

Nullcline Analysis Provides Dynamic Mechanisms for the Differences in Electrical Activity of Distinct Subpopulations of Midbrain Dopamine NeuronsSemantic proximity Read ↗

Ca <sup>2+</sup> -dependent phosphodiesterase 1 regulates the plasticity of striatal spiny projection neuron glutamatergic synapsesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.