Article
A Multi-Marker Genetic Association Test Based on the Rasch Model Applied to Alzheimer's Disease.
PloS one - 1 Jan 2015
Wang Wenjia, Mandel Jonas, Bouaziz Jan, Commenges Daniel, Nabirotchkine Serguei, Chumakov Ilya, Cohen Daniel, Guedj Mickaël
Abstract excerpt
Results from Genome-Wide Association Studies (GWAS) have shown that the genetic basis of complex traits often include many genetic variants with small to moderate effects whose identification remains a challenging problem. In this context multi-marker analysis at the gene and pathway level can complement traditional point-wise approaches that treat the genetic markers individually. In this paper we propose a...
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