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Article

A machine learning-based SNP-set analysis approach for identifying disease-associated susceptibility loci.

Scientific reports - 22 Sept 2022

Silva Princess P, Gaudillo Joverlyn D, Vilela Julianne A, Roxas-Villanueva Ranzivelle Marianne L, Tiangco Beatrice J, Domingo Mario R, Albia Jason R

Abstract excerpt

Identifying disease-associated susceptibility loci is one of the most pressing and crucial challenges in modeling complex diseases. Existing approaches to biomarker discovery are subject to several limitations including underpowered detection, neglect for variant interactions, and restrictive dependence on prior biological knowledge. Addressing these challenges necessitates more ingenious ways of approaching the...

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Identifiers

PMID: 36138111
DOI: 10.1038/s41598-022-19708-1
PMCID: PMC9499949

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