Article
Enriching the analysis of genomewide association studies with hierarchical modeling.
American journal of human genetics - 1 Aug 2007
Chen Gary K, Witte John S
Abstract excerpt
Genomewide association studies (GWAs) initially investigate hundreds of thousands of single-nucleotide polymorphisms (SNPs), and the most promising SNPs are further evaluated with additional subjects, for replication or a joint analysis. Deciding which SNPs merit follow-up is one of the most crucial aspects of these studies. We present here an approach for selecting the most-promising SNPs that incorporates into...
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