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Article

Structural Basis of Neuronal Nitric-oxide Synthase Interaction with Dystrophin Repeats 16 and 17.

The Journal of biological chemistry - 4 Dec 2015

Molza Anne-Elisabeth, Mangat Khushdeep, Le Rumeur Elisabeth, Hubert Jean-François, Menhart Nick, Delalande Olivier

Abstract excerpt

Duchenne muscular dystrophy is a lethal genetic defect that is associated with the absence of dystrophin protein. Lack of dystrophin protein completely abolishes muscular nitric-oxide synthase (NOS) function as a regulator of blood flow during muscle contraction. In normal muscles, nNOS function is ensured by its localization at the sarcolemma through an interaction of its PDZ domain with dystrophin spectrin-like...

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Identifiers

PMID: 26378238
DOI: 10.1074/jbc.M115.680660
PMCID: PMC4705953

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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