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Article

Effect of Methionine Oxidation and Substitution of α-Conotoxin TxID on α3β4 Nicotinic Acetylcholine Receptor.

Marine drugs - 20 Jun 2018

Ren Jie, Li Rui, Ning Jiong, Zhu Xiaopeng, Zhangsun Dongting, Wu Yong, Luo Sulan

Abstract excerpt

α-Conotoxin TxID was discovered from Conus textile by gene cloning, which has 4/6 inter-cysteine loop spacing and selectively inhibits α3β4 nicotinic acetylcholine receptor (nAChR) subtype. However, TxID is susceptible to modification due to it containing a methionine (Met) residue that easily forms methionine sulfoxide (MetO) in oxidative environment. In this study, we investigated how Met-11...

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Identifiers

PMID: 29925760
DOI: 10.3390/md16060215
PMCID: PMC6025358

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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