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Article

Formation of nNOS/PSD-95 PDZ dimer requires a preformed beta-finger structure from the nNOS PDZ domain.

Journal of molecular biology - 27 Oct 2000

Tochio H, Mok Y K, Zhang Q, Kan H M, Bredt D S, Zhang M

Abstract excerpt

PDZ domains are modular protein units that play important roles in organizing signal transduction complexes. PDZ domains mediate interactions with both C-terminal peptide ligands and other PDZ domains. Here, we used PDZ domains from neuronal nitric oxide synthase (nNOS) and postsynaptic density protein-95 (PSD-95) to explore the mechanism for PDZ-dimer formation. The nNOS PDZ domain terminates with a...

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Source

Identifiers

PMID: 11031113
DOI: 10.1006/jmbi.2000.4148

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PSD

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Formation of nNOS/PSD-95 PDZ dimer requires a preformed beta-finger structure from the nNOS PDZ domain.PMID 11031113Read ↗

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Structural basis for PDZ domain interactions in the post-synaptic density scaffolding protein Shank3.Semantic proximity Read ↗

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