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[Solid-phase synthesis and biological characterization of S12A-HNTX-IV and R29A-HNTX-IV: two mutants of hainantoxin-IV].

Sheng wu gong cheng xue bao = Chinese journal of biotechnology - 1 Jan 2005

Xu Xia, Xiong Xia, Li Dong-Ling, Xiao Yu-Cheng, Wang Xian-Chun, Liang Song-Ping

Abstract excerpt

Hainantoxin-IV (HNTX-IV) purified from the venom of the spider Selenocosmia hainana is a potent antagonist that acts on tetrodotoxin-sensitive (TrX-S) sodium channels. It is a 35-residue polypeptide and includes three disulfide bridges. In order to investigate the structure-function relationship of HNTX-IV, two mutants (S12A-HNTX-IV and R29A-HNTX-IV) of HNTX-TV in which Ser12 and Arg29 were replaced by Ala...

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PMID: 15859335

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