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Article

Crystal structures of constitutive nitric oxide synthases in complex with de novo designed inhibitors.

Journal of medicinal chemistry - 9 Apr 2009

Igarashi Jotaro, Li Huiying, Jamal Joumana, Ji Haitao, Fang Jianguo, Lawton Graham R, Silverman Richard B, Poulos Thomas L

Abstract excerpt

New nitric oxide synthase (NOS) inhibitors were designed de novo with knowledge gathered from the studies on the nNOS-selective dipeptide inhibitors. Each of the new inhibitors consists of three fragments: an aminopyridine ring, a pyrrolidine, and a tail of various length and polarity. The in vitro inhibitory assays indicate good potency and isoform selectivity for some of the compounds. Crystal structures of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19296678
DOI: 10.1021/jm900007a
PMCID: PMC3103786

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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