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Article

Electrostatic Control of Isoform Selective Inhibitor Binding in Nitric Oxide Synthase.

Biochemistry - 5 Jul 2016

Li Huiying, Wang Heng-Yen, Kang Soosung, Silverman Richard B, Poulos Thomas L

Abstract excerpt

Development of potent and isoform selective nitric oxide synthase (NOS) inhibitors is challenging because of the structural similarity in the heme active sites. One amino acid difference between NOS isoforms, Asp597 in rat neuronal NOS (nNOS) versus Asn368 in bovine endothelial NOS (eNOS), has been identified as the structural basis for why some dipeptide amide inhibitors bind more tightly to nNOS than to eNOS....

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Identifiers

PMID: 27250740
DOI: 10.1021/acs.biochem.6b00261
PMCID: PMC5287043

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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