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Article

Pharmacogenetic effect of the UGT polymorphisms on mycophenolate is modified by calcineurin inhibitors.

European journal of clinical pharmacology - 1 Nov 2008

Johnson L'aurelle A, Oetting William S, Basu Saonli, Prausa Susie, Matas Arthur, Jacobson Pamala A

Abstract excerpt

BACKGROUND: Mycophenolic acid (MPA) is glucuronidated primarily by uridine diphosphate glucuronosyltransferase enzymes (UGT) 1A9 and 1A8. These enzymes are highly polymorphic resulting in low activity and high expression phenotypes. We hypothesized that polymorphisms of UGT1A9 and 1A8 may alter MPA pharmacokinetics in kidney transplantation. METHODS: One hundred seventeen kidney (n = 93), pancreas (n = 11), or...

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Source

Identifiers

PMID: 18568343
DOI: 10.1007/s00228-008-0501-y

Genes

UGT1A9
UGT1A8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Pharmacogenetic effect of the UGT polymorphisms on mycophenolate is modified by calcineurin inhibitors.PMID 18568343Read ↗

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Influence of genetic polymorphisms on pharmacokinetics and treatment response of mycophenolic acid: a scoping reviewSemantic proximity Read ↗

The main role of UGT1A9 in the hepatic metabolism of mycophenolic acid and the effects of naturally occurring variants.Semantic proximity Read ↗

The Impact of Genetic Polymorphisms on the Pharmacokinetics and Pharmacodynamics of Mycophenolic Acid: Systematic Review and Meta-analysis.Semantic proximity Read ↗

Influence of Genetic Polymorphisms on Mycophenolic Acid Pharmacokinetics and Patient Outcomes in Renal Transplantation.Semantic proximity Read ↗

UGT1A9, UGT2B7, and MRP2 genotypes can predict mycophenolic acid pharmacokinetic variability in pediatric kidney transplant recipients.Semantic proximity Read ↗

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