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Article

A secretory leukocyte protease inhibitor variant with improved activity against lung infection.

Mucosal immunology - 1 May 2016

Camper N, Glasgow A M A, Osbourn M, Quinn D J, Small D M, McLean D T, Lundy F T, Elborn J S, McNally P, Ingram R J, Weldon S, Taggart C C

Abstract excerpt

Secretory leukocyte protease inhibitor (SLPI) is an important respiratory tract host defense protein, which is proteolytically inactivated by excessive neutrophil elastase (NE) during chronic Pseudomonas infection in the cystic fibrosis (CF) lung. We generated two putative NE-resistant variants of SLPI by site-directed mutagenesis, SLPI-A16G and SLPI-S15G-A16G, with a view to improving SLPI's proteolytic...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 26376365
DOI: 10.1038/mi.2015.90

Genes

SLPI

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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