Article
The antibacterial and antifungal properties of trappin-2 (pre-elafin) do not depend on its protease inhibitory function.
The FEBS journal - 1 May 2008
Baranger Kévin, Zani Marie-Louise, Chandenier Jacques, Dallet-Choisy Sandrine, Moreau Thierry
Abstract excerpt
Trappin-2 (also known as pre-elafin) is an endogenous inhibitor of neutrophil serine proteases and is involved in the control of excess proteolysis, especially in inflammatory events, along with the structurally related secretory leucocyte proteinase inhibitor. Secretory leucocyte proteinase inhibitor has been shown to have antibacterial and antifungal properties, whereas recent data indicate that trappin-2 has...
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