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SLPI and elafin: multifunctional antiproteases of the WFDC family

21 Sept 2011

Abstract excerpt

SLPI (secretory leucoprotease inhibitor) and elafin represent the archetypal members of the WFDC [WAP (whey acidic protein) four disulfide core] family of proteins, and were originally characterized as protease inhibitors but have since been shown to possess a wider repertoire of activities. These functions include antimicrobial and immunomodulatory properties, suggesting that these proteins may play key roles in...

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PMID: 21936829
DOI: 10.1042/bst0391437

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