Article
Low-Frequency IL23R Coding Variant Associated with Crohn's Disease Susceptibility in Japanese Subjects Identified by Personal Genomics Analysis.
PloS one - 1 Jan 2015
Onodera Kei, Arimura Yoshiaki, Isshiki Hiroyuki, Kawakami Kentaro, Nagaishi Kanna, Yamashita Kentaro, Yamamoto Eiichiro, Niinuma Takeshi, Naishiro Yasuyoshi, Suzuki Hiromu, Imai Kohzoh, Shinomura Yasuhisa
Abstract excerpt
BACKGROUND: The common disease-common variant hypothesis is insufficient to explain the complexities of Crohn's disease (CD) genetics; therefore, rare variants are expected to be important in the disease. We explored rare variants associated with susceptibility to CD in Japanese individuals by personal genomic analysis. METHODS: Two-step analyses were performed. The first step was a trio analysis with whole-exome...
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