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Article

Single Amino Acid Polymorphisms of Pertussis Toxin Subunit S2 (PtxB) Affect Protein Function.

PloS one - 1 Jan 2015

Millen Scott H, Watanabe Mineo, Komatsu Eiji, Yamaguchi Fuminori, Nagasawa Yuki, Suzuki Eri, Monaco Haleigh, Weiss Alison A

Abstract excerpt

Whooping cough due to Bordetella pertussis is increasing in incidence, in part due to accumulation of mutations which increase bacterial fitness in highly vaccinated populations. Polymorphisms in the pertussis toxin, ptxA and ptxB genes, and the pertactin, prn genes of clinical isolates of Bordetella pertussis collected in Cincinnati from 1989 through 2005 were examined. While the ptxA and prn genotypes were...

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Identifiers

PMID: 26375454
DOI: 10.1371/journal.pone.0137379
PMCID: PMC4573519

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Source receipt: pubmed, retrieved 7 Sept 2026.

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