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Article

Differential IKK/NF-κB Activity Is Mediated by TSC2 through mTORC1 in PTEN-Null Prostate Cancer and Tuberous Sclerosis Complex Tumor Cells.

Molecular cancer research : MCR - 1 Dec 2015

Gao Yu, Gartenhaus Ronald B, Lapidus Rena G, Hussain Arif, Zhang Yanting, Wang Xinghuan, Dan Han C

Abstract excerpt

UNLABELLED: The serine/threonine protein kinase Akt plays a critical role in regulating proliferation, growth, and survival through phosphorylation of different downstream substrates. The mTOR is a key target for Akt to promote tumorigenesis. It has been reported that Akt activates mTOR through phosphorylation and inhibition of the tuberous sclerosis complex (TSC) protein TSC2. Previously, it was demonstrated...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 26374334
DOI: 10.1158/1541-7786.MCR-15-0213
PMCID: PMC4690470

Genes

TSC2
PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Differential IKK/NF-κB Activity Is Mediated by TSC2 through mTORC1 in PTEN-Null Prostate Cancer and Tuberous Sclerosis Complex Tumor Cells.PMID 26374334Read ↗

Akt-dependent activation of mTORC1 complex involves phosphorylation of mTOR (mammalian target of rapamycin) by IκB kinase α (IKKα).Semantic proximity Read ↗

TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling.Semantic proximity Read ↗

Regulation of mammalian target of rapamycin activity in PTEN-inactive prostate cancer cells by I kappa B kinase alpha.Semantic proximity Read ↗

Loss of Tuberous Sclerosis Complex 2 confers inflammation via dysregulation of Nuclear factor kappa-light-chain-enhancer of activated B cellsSemantic proximity Read ↗

Differential impact of PI3K/AKT/mTOR signaling on tumor initiation and progression in animal models of prostate cancer.Semantic proximity Read ↗

Modulation of TSC-mTOR signaling on immune cells in immunity and autoimmunitySemantic proximity Read ↗

Mechanism of Akt1 inhibition of breast cancer cell invasion reveals a protumorigenic role for TSC2Semantic proximity Read ↗

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mTOR complex 2 is required for the development of prostate cancer induced by Pten loss in mice.Semantic proximity Read ↗

Genetic analysis of Pten and Tsc2 functional interactions in the mouse reveals asymmetrical haploinsufficiency in tumor suppression.Semantic proximity Read ↗

The NF1 tumor suppressor critically regulates TSC2 and mTORSemantic proximity Read ↗

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