Article

Loss of Tuberous Sclerosis Complex 2 confers inflammation via dysregulation of Nuclear factor kappa-light-chain-enhancer of activated B cells

2024-07-15

Abstract excerpt

<title>Abstract</title> Background Aberrant activation of mTORC1 is clearly defined in TSC, causing uncontrolled cell growth. While mTORC1 inhibitors show efficacy to stabilise tumour growth in TSC, they are not fully curative. Disease facets of TSC that are not restored with mTOR inhibitors might involve NF-κB. The study aimed to characterise NF-κB in the context of TSC. Results Enrichment of NF-κB-regulate...

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Literature Corpus work: 77d68826-877d-5c2a-889a-c046a2d87b62
DOI: 10.21203/rs.3.rs-4569999/v1

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