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Article

Akt and mTORC1 have different roles during liver tumorigenesis in mice.

Gastroenterology - 1 May 2013

Kenerson Heidi L, Yeh Matthew M, Kazami Machiko, Jiang Xiuyun, Riehle Kimberly J, McIntyre Rebecca L, Park James O, Kwon Steve, Campbell Jean S, Yeung Raymond S

Abstract excerpt

BACKGROUND & AIMS: Phosphatidylinositide 3-kinase (PI3K) is deregulated in many human tumor types, including primary liver malignancies. The kinase v-akt murine thymoma viral oncogene homolog 1 (Akt) and mammalian target of rapamycin complex (mTORC1) are effectors of PI3K that promote cell growth and survival, but their individual roles in tumorigenesis are not well defined. METHODS: In livers of albumin...

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Share to Carcinoma, Hepatocellular
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Liver Neoplasms, Experimental

Share to Mechanistic Target of Rapamycin Complex 1

Share to Multiprotein Complexes

Share to Proto-Oncogene Proteins c-akt

Share to RNA, Neoplasm

Share to TOR Serine-Threonine Kinases

Source

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Identifiers

PMID: 23376645
DOI: 10.1053/j.gastro.2013.01.053
PMCID: PMC3633657

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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