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Article

Regulation of COX-2 protein expression by Akt in endometrial cancer cells is mediated through NF-kappaB/IkappaB pathway.

1 Jan 2004

Abstract excerpt

BACKGROUND: Cyclooxygenase-2 (COX-2) has been shown to be highly expressed in a broad series of primary endometrial tumors and its expression may be closely associated with parameters of tumor aggressiveness. In human endometrial cancer, tumor suppressor phosphatase tensin homologue (PTEN) is frequently mutated. In the presence of a mutated PTEN protein, Akt phosphorylation levels increase leading to the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 15016316
DOI: 10.1186/1476-4598-3-7

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Regulation of COX-2 protein expression by Akt in endometrial cancer cells is mediated through NF-kappaB/IkappaB pathway.PMID 15016316Read ↗

Akt regulates COX-2 mRNA and protein expression in mutated-PTEN human endometrial cancer cells.Semantic proximity Read ↗

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Growth suppression activity of the PTEN tumor suppressor gene in human endometrial cancer cells.Semantic proximity Read ↗

In vivo and in vitro regulation of Akt activation in human endometrial cells is estrogen dependent.Semantic proximity Read ↗

Somatic mutations are present in all members of the AKT family in endometrial carcinomaSemantic proximity Read ↗

Akt stimulates the transactivation potential of the RelA/p65 Subunit of NF-kappa B through utilization of the Ikappa B kinase and activation of the mitogen-activated protein kinase p38.Semantic proximity Read ↗

AKT1 pleckstrin homology domain E17K activating mutation in endometrial carcinoma.Semantic proximity Read ↗

Akt Fine-tunes NF-κB-dependent Gene Expression during T Cell ActivationSemantic proximity Read ↗

Activation of extracellular regulated kinases (ERK1/2) but not AKT predicts poor prognosis in colorectal carcinoma and is associated with k-ras mutations.Semantic proximity Read ↗

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