Article
Expression, prognostic significance and mutational analysis of protein tyrosine phosphatase SHP-1 in chronic myeloid leukemia.
Leukemia & lymphoma - 1 May 2016
Papadopoulou Vasiliki, Kontandreopoulou Elina, Panayiotidis Panayiotis, Roumelioti Maria, Angelopoulou Maria, Kyriazopoulou Lydia, Diamantopoulos Panagiotis T, Vaiopoulos George, Variami Eleni, Kotsianidis Ioannis, Athina Viniou Nora
Abstract excerpt
The protein tyrosine phosphatase SHP-1 dephosphorylates BCR-ABL1, thereby serving as a potential control mechanism of BCR-ABL1 kinase activity. Pathways regulating SHP-1 expression, which could be exploited in the therapeutics of TKI-resistant chronic myeloid leukemia (CML), remain unknown. Moreover, the questions of whether there is any kind of SHP-1 deregulation in CML, contributing to disease initiation or...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.