Article
Mutation analysis of hematopoietic cell phosphatase gene in acute leukemia.
Zhongguo shi yan xue ye xue za zhi - 1 Apr 2004
Luo Jian-Min, Liu Ze-Lin, Hao Hong-Ling, Wang Fu-Xu, Dong Zuo-Ren, Ryuzo Ohno
Abstract excerpt
The hematopoietic cell phosphatase (HCP or SHP-1), the SH2 domain contain protein tyrosine phosphatase, is a crucial negative regulator in the process of hematopoietic cell development, proliferation and receptor-mediated mitogenic signaling pathways, and its mutation is responsible for the over-expansion and inappropriate activation of myelomonocytic population in motheaten mice. The aim of the study was to...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.