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Article

FLT3/ITD mutation signaling includes suppression of SHP-1.

The Journal of biological chemistry - 18 Feb 2005

Chen Peili, Levis Mark, Brown Patrick, Kim Kyu-Tae, Allebach Jeffrey, Small Donald

Abstract excerpt

Mutations in the FLT3 gene are the most common genetic alteration found in AML patients. FLT3 internal tandem duplication (ITD) mutations result in constitutive activation of FLT3 tyrosine kinase activity. The consequences of this activation are an increase in total phosphotyrosine content, persistent downstream signaling, and ultimately transformation of hematopoietic cells to factor-independent growth. The Src...

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Source

Identifiers

PMID: 15574429
DOI: 10.1074/jbc.M411974200

Genes

FLT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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FLT3/ITD mutation signaling includes suppression of SHP-1.PMID 15574429Read ↗

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