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Article

Radon Exposure, IL-6 Promoter Variants, and Lung Squamous Cell Carcinoma in Former Uranium Miners.

Environmental health perspectives - 1 Apr 2016

Leng Shuguang, Thomas Cynthia L, Snider Amanda M, Picchi Maria A, Chen Wenshu, Willis Derall G, Carr Teara G, Krzeminski Jacek, Desai Dhimant, Shantu Amin, Lin Yong, Jacobson Marty R, Belinsky Steven A

Abstract excerpt

BACKGROUND: High radon exposure is a risk factor for squamous cell carcinoma, a major lung cancer histology observed in former uranium miners. Radon exposure can cause oxidative stress, leading to pulmonary inflammation. Interleukin-6 (IL-6) is a pro-carcinogenic inflammatory cytokine that plays a pivotal role in lung cancer development. OBJECTIVES: We assessed whether single nucleotide polymorphisms (SNPs) in...

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Identifiers

PMID: 26372664
DOI: 10.1289/ehp.1409437
PMCID: PMC4829998

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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