Genetic modifiers of radon-induced lung cancer risk: a genome-wide interaction study in former uranium miners.

doi:10.1007/s00420-018-1334-3

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Article

Genetic modifiers of radon-induced lung cancer risk: a genome-wide interaction study in former uranium miners.

International archives of occupational and environmental health - 1 Nov 2018

Rosenberger Albert, Hung Rayjean J, Christiani David C, Caporaso Neil E, Liu Geoffrey, Bojesen Stig E, Le Marchand Loic, Haiman Ch A, Albanes Demetrios, Aldrich Melinda C, Tardon Adonina, Fernández-Tardón G, Rennert Gad, Field John K, Kiemeney B, Lazarus Philip, Haugen Aage, Zienolddiny Shanbeh, Lam Stephen, Schabath Matthew B, Andrew Angeline S, Brunnsstöm Hans, Goodman Gary E, Doherty Jennifer A, Chen Chu, Teare M Dawn, Wichmann H-Erich, Manz Judith, Risch Angela, Muley Thomas R, Johansson Mikael, Brennan Paul, Landi Maria Teresa, Amos Christopher I, Pesch Beate, Johnen Georg, Brüning Thomas, Bickeböller Heike, Gomolka Maria

Abstract excerpt

PURPOSE: Radon is a risk factor for lung cancer and uranium miners are more exposed than the general population. A genome-wide interaction analysis was carried out to identify genomic loci, genes or gene sets that modify the susceptibility to lung cancer given occupational exposure to the radioactive gas radon. METHODS: Samples from 28 studies provided by the International Lung Cancer Consortium were pooled with...

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PMID: 29971594
DOI: 10.1007/s00420-018-1334-3
PMCID: PMC6375683

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CHRNB4

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