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Article

Genetic variation in SIRT1 affects susceptibility of lung squamous cell carcinomas in former uranium miners from the Colorado plateau.

Carcinogenesis - 1 May 2013

Leng Shuguang, Picchi Maria A, Liu Yushi, Thomas Cynthia L, Willis Derall G, Bernauer Amanda M, Carr Teara G, Mabel Padilla T, Han Younghun, Amos Christopher I, Lin Yong, Stidley Christine A, Gilliland Frank D, Jacobson Marty R, Belinsky Steven A

Abstract excerpt

Epidemiological studies of underground miners suggested that occupational exposure to radon causes lung cancer with squamous cell carcinoma (SCC) as the predominant histological type. However, the genetic determinants for susceptibility of radon-induced SCC in miners are unclear. Double-strand breaks induced by radioactive radon daughters are repaired primarily by non-homologous end joining (NHEJ) that is...

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Identifiers

PMID: 23354305
DOI: 10.1093/carcin/bgt024
PMCID: PMC3643420

Genes

SIRT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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