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Article

High CO2 Leads to Na,K-ATPase Endocytosis via c-Jun Amino-Terminal Kinase-Induced LMO7b Phosphorylation.

Molecular and cellular biology - 1 Dec 2015

Dada Laura A, Trejo Bittar Humberto E, Welch Lynn C, Vagin Olga, Deiss-Yehiely Nimrod, Kelly Aileen M, Baker Mairead R, Capri Joseph, Cohn Whitaker, Whitelegge Julian P, Vadász István, Gruenbaum Yosef, Sznajder Jacob I

Abstract excerpt

The c-Jun amino-terminal kinase (JNK) plays a role in inflammation, proliferation, apoptosis, and cell adhesion and cell migration by phosphorylating paxillin and β-catenin. JNK phosphorylation downstream of AMP-activated protein kinase (AMPK) activation is required for high CO2 (hypercapnia)-induced Na,K-ATPase endocytosis in alveolar epithelial cells. Here, we provide evidence that during hypercapnia, JNK...

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Identifiers

PMID: 26370512
DOI: 10.1128/MCB.00813-15
PMCID: PMC4628060

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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