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Article

Phosphorylation of adaptor protein-2 mu2 is essential for Na+,K+-ATPase endocytosis in response to either G protein-coupled receptor or reactive oxygen species.

American journal of respiratory cell and molecular biology - 1 Jul 2006

Chen Zongpei, Krmar Rafael T, Dada Laura, Efendiev Riad, Leibiger Ingo B, Pedemonte Carlos H, Katz Adrian I, Sznajder Jacob I, Bertorello Alejandro M

Abstract excerpt

Activation of G protein-coupled receptor by dopamine and hypoxia-generated reactive oxygen species promote Na+,K+-ATPase endocytosis. This effect is clathrin dependent and involves the activation of protein kinase C (PKC)-zeta and phosphorylation of the Na+,K+-ATPase alpha-subunit. Because the incorporation of cargo into clathrin vesicles requires association with adaptor proteins, we studied whether...

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Identifiers

PMID: 16498080
DOI: 10.1165/rcmb.2006-0044OC
PMCID: PMC2658693

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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