Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Phosphorylation and ubiquitination are necessary for Na,K-ATPase endocytosis during hypoxia.

Cellular signalling - 1 Sept 2007

Dada Laura A, Welch Lynn C, Zhou Guofei, Ben-Saadon Ronen, Ciechanover Aaron, Sznajder Jacob I

Abstract excerpt

As a cellular adaptative response, hypoxia decreases Na,K-ATPase activity by triggering the endocytosis of its alpha(1) subunit in alveolar epithelial cells. Here, we present evidence that the ubiquitin conjugating system is important in the Na,K-ATPase endocytosis during hypoxia and that ubiquit...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Lysine
Share to Cell Hypoxia
Share to CHO Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cricetulus

Share to Endocytosis

Share to Phosphoserine

Share to Sodium-Potassium-Exchanging ATPase

Share to Ubiquitin

Source

Open in PubMed Open full text

Identifiers

PMID: 17532187
DOI: 10.1016/j.cellsig.2007.04.013
PMCID: PMC2039720

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17532187-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Phosphorylation and ubiquitination are necessary for Na,K-ATPase endocytosis during hypoxia.PMID 17532187Read ↗

HIF and HOIL-1L-mediated PKCζ degradation stabilizes plasma membrane Na,K-ATPase to protect against hypoxia-induced lung injury.Semantic proximity Read ↗

Hypoxia-induced endocytosis of Na,K-ATPase in alveolar epithelial cells is mediated by mitochondrial reactive oxygen species and PKC-zeta.Semantic proximity Read ↗

Phosphorylation of adaptor protein-2 mu2 is essential for Na+,K+-ATPase endocytosis in response to either G protein-coupled receptor or reactive oxygen species.Semantic proximity Read ↗

Three ubiquitination sites of organic anion transporter-1 synergistically mediate protein kinase C-dependent endocytosis of the transporter.Semantic proximity Read ↗

EGF receptor ubiquitination is not necessary for its internalization.Semantic proximity Read ↗

Ubiquitination differentially regulates clathrin-dependent internalization of protease-activated receptor-1.Semantic proximity Read ↗

Tyrosine 537 within the Na+,K+-ATPase alpha-subunit is essential for AP-2 binding and clathrin-dependent endocytosis.Semantic proximity Read ↗

Short-chain ubiquitination mediates the regulated endocytosis of the aquaporin-2 water channel.Semantic proximity Read ↗

Clathrin-mediated endocytosis of Na+,K+-ATPase in response to parathyroid hormone requires ERK-dependent phosphorylation of Ser-11 within the alpha1-subunit.Semantic proximity Read ↗

Ubiquitination-activating enzymes UBE1 and UBA6 regulate ubiquitination and expression of cardiac sodium channel Nav1.5.Semantic proximity Read ↗

Nedd4-2 phosphorylation induces serum and glucocorticoid-regulated kinase (SGK) ubiquitination and degradation.Semantic proximity Read ↗

Ubiquitylation of ion channels.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.