Article
WNK4 kinase regulates surface expression of the human sodium chloride cotransporter in mammalian cells.
Kidney international - 1 Jun 2006
Cai H, Cebotaru V, Wang Y-H, Zhang X-M, Cebotaru L, Guggino S E, Guggino W B
Abstract excerpt
Pseudohypoaldosteronism type II (PHA II) is caused by mutations of two members of WNK ((with no lysine (k)) kinase family. WNK4 wild type (WT) has been shown to inhibit the activity and surface expression of sodium chloride cotransporter (NCC) when expressed in Xenopus oocytes. Here, we have studied NCC protein processing in mammalian cells in the presence or absence of WNK4 WT and its mutants, E562K and R1185C,...
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